Senior Scientist 1

About the Opportunity

As a result of ongoing growth within the Preclinical Services at Revvity Cambridge (formerly Horizon Discovery) we have an exciting opportunity to join our team as a Senior Scientist team working on our state-of-the-art pooled CRISPR-Cas9 screening platform. Working within an inclusive environment, you will use CRISPR-Cas9 technologies to identify novel gene-gene and drug-gene interactions for target ID and patient stratification, for our clients.

For this lab-based Senior Scientist role, you will be responsible for designing, developing, and delivering innovative and complex pooled CRISPR screening assays in cell-based model systems. Successful candidates will have a strong R&D background, are highly self-motivated, able to work to tight timelines and are comfortable working in a dynamic, collaborative, environment.

In this role you will:

• Independently plan and perform complex pooled CRISPR-Cas9 screening experiments in accordance with project aims and specification, with minimal supervision

• Engage with customers and Revvity colleagues on a scientific level to understand research requirements and successfully deliver data that answers the key scientific questions

• Interpret experimental data, troubleshoot, discuss results and identify next steps.

• Prepare high quality client facing data packages and reports, clearly disseminating the results of your work

• Maintain an awareness of current and emerging techniques / technologies and apply these to your research

• Guide and mentor other team members

• Follow and give instructions, comply with company policies and be an effective team member pro-actively supporting the research and development functions in Revvity.

About You:

To succeed in this role, you will need:

• A minimum of four years relevant work experience after PhD or equivalent experience.

• A strong background in a relevant disease area and the ability to quickly learn new techniques and areas of biology

• Extensive experience of mammalian cell culture, excellent aseptic technique and performing various cell-based assays, such as those commonly employed at Revvity.

• Proven experience and enthusiasm for using, adapting and developing cell-based screening assays

• Proven ability to disseminate research results e.g. in reports, presentations and peer reviewed journal publications

• Excellent interpersonal and communication skills, both written and verbal

• Flexible and able to work in a dynamic environment

• Excellent planning/organizational skills with a careful and meticulous nature

• Ability to perform multiple tasks simultaneously, keep accurate records

• Follow and give instructions, and comply with company policies

You may also have:

• Experience of high-throughput assays, use of automation, scripting (for example in R or Python etc) and handling large datasets including data QC, analysis, generating relevant graphical representations

• Experience with transfection, transduction and techniques to modulate gene expression in mammalian cell models e.g. CRISPR-Cas9, siRNA, shRNA etc.

• Safe handling and production of lentiviral reagents

• Experience of working in an industrial setting

If you have experience with CRISPR-Cas9 or compound screening and a keen interest in applying these technologies to clinically relevant applications in a collaborative, team environment, to help our customers and aid drug-discovery then click on the link and apply below to start your screening journey with Revvity!